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4-hydroperoxy cyclophosphamide
CAS No. 39800-16-3
4-hydroperoxy cyclophosphamide( —— )
Catalog No. M34777 CAS No. 39800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 350 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name4-hydroperoxy cyclophosphamide
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NoteResearch use only, not for human use.
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Brief Description4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.
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Description4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases.
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In VitroWestern Blot Analysis Cell Line:CTL Concentration:3 μg/mL Incubation Time:24, 48, 72 hResult:Increased the expression of p53 and Bax after 24 h.Apoptosis Analysis Cell Line:Jurkat, CTL Concentration:1 or 3 μg/mL Incubation Time:24 , 48 , 72h Result: Caspase-8 deficiency prevented CD95-mediated death induced by anti-CD95 monoclonal antibody (mAb) APO-1.Overexpression of Bcl-2 inhibited apoptosis. Induced cell death proceeded independently of caspase inhibition.
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In VivoAnimal Model:BALB/c mice Dosage:200 mg/kg Administration:i.p.Result:Exhibited a marked depletion of immature double-positive CD4 t CD8 t thymocytes and mature single-positive CD4+ and CD8+ T cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorReactive Oxygen Species | DNA Alkylator/Crosslinker | Apoptosis | Drug Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number39800-16-3
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Formula Weight293.09
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Molecular FormulaC7H15Cl2N2O4P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (170.60 mM; Ultrasonic )
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SMILESO=P1(OCCC(OO)N1)N(CCCl)CCCl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43.?
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